Ixorine, a New Cyclopeptide Alkaloid from the Branches of Ixora brevifolia

Journal of the Brazilian Chemical Society

Pomini, Armando M.¹  Silva, Cleuza C.¹  Universidade Estadual de Maringá, Maringá, Brazil¹  Nakamura, Celso V.¹  Kato, Lucília¹  Oliveira, Cecília M. A.¹  Universidade Federal de Goiás, Goiânia, Brazil¹  Santin, Silvana M. O.¹  Schuquel, Ivânia T. A.¹  Medina, Rebeca P.¹ 

关键词:  Ixora brevifolia;    Rubiaceae;    cyclopeptide alkaloids;    Leishmania;   

DOI  :  10.5935/0103-5053.20150326

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

The isolation and structure determination of new cyclic peptide alkaloid ixorine, along with five known constituents frangulanine, syringaresinol, cinnamtannin B-1, daucosterol and mannitol from the branches of Ixora brevifolia are described. The cyclic peptide frangulanine is being described for the first time in the Rubiaceae family. The structures were elucidated on their spectral data basis, mainly one- (1H, 13C, DEPT) and two-dimensional (COSY, NOESY, HSQC and HMBC) nuclear magnetic resonance (NMR) and by comparison with data from the literature. The mixture of two cyclopeptide alkaloids showed weak activity against Leishmania amazonensis.

【 授权许可】

Unknown