Briacavatolides D–F, New Briaranes from the Taiwanese Octocoral Briareum excavatum

Marine Drugs

Shang-Kwei Wang²  Tsun-Tai Yeh¹ 

[1] Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan;Asia-Pacific Ocean Research Center, National Sun Yat-Sen University, Kaohsiung 804, Taiwan;

关键词: Briareum excavatum;    briarane-type diterpenoid;    cytotoxicity;    anti-HCMV;   

DOI  :  10.3390/md10092103

来源: mdpi

【 摘 要 】

In the continued search for novel bioactive substances from the Taiwanese octocoral Briareum excavatum collected at Orchid Island, three new briarane-type diterpenoids, briacavatolides D–F (1–3) were isolated from the acetone extract. The structures of these compounds were elucidated by extensive NMR spectroscopic analysis and physical data. The anti-HCMV (human cytomegalovirus) activity of 1–3 and their cytotoxicity against selected cancer cell lines were evaluated.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.