Functional and Structural Brain Changes Associated with Methamphetamine Abuse

Brain Sciences

Reem K. Jan¹  Rob R. Kydd² 

[1] School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand;Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand;

关键词: addiction;    cognitive control;    decision-making;    dopamine;    grey matter;    functional magnetic resonance imaging;    methamphetamine;    neurotoxicity;    positron emission tomography;    serotonin;   

DOI  :  10.3390/brainsci2040434

来源: mdpi

【 摘 要 】

Methamphetamine (MA) is a potent psychostimulant drug whose abuse has become a global epidemic in recent years. Firstly, this review article briefly discusses the epidemiology and clinical pharmacology of methamphetamine dependence. Secondly, the article reviews relevant animal literature modeling methamphetamine dependence and discusses possible mechanisms of methamphetamine-induced neurotoxicity. Thirdly, it provides a critical review of functional and structural neuroimaging studies in human MA abusers; including positron emission tomography (PET) and functional and structural magnetic resonance imaging (MRI). The effect of abstinence from methamphetamine, both short- and long-term within the context of these studies is also reviewed.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.