Synthesis and Herbicidal Activity of Substituted Pyrazole Isothiocyanates

Molecules

Hua Wu¹  Jun-Tao Feng¹  Kai-Chun Lin² 

[1] Research & Development Center of Biorational Pesticide, Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, Northwest A&F University, Yangling 712100, Shaanxi, China;Hubei Green-Tiandi Bioengineering Co., Ltd, Wuhan 430070, Hubei, China

关键词: substituted pyrazoles;    isothiocyanates;    synthesis;    herbicidal activity;   

DOI  :  10.3390/molecules171012187

来源: mdpi

【 摘 要 】

Isothiocyanates and substituted pyrazoles were combined to form a series of novel isothiocyanates with highly effective herbicidal activity. The target compounds were analyzed by elemental analysis, ¹H-NMR, EI-MS and IR spectroscopy. The synthesized compounds, particularly compounds 3-1 and 3-7, exhibited good herbicidal activities against four weeds. The EC₅₀ values of compound 3-1 against Echinochloa crusgalli L., Cyperus iria L., Dactylis glomerata L., and Trifolium repens L. were 64.32, 65.83, 62.42, and 67.72 µg/mL, respectively. The EC₅₀ values of compound 3-7 against E. crusgalli L., C. iria L., D. glomerata L., T. repens L. were 65.33, 64.90, 59.41 and 67.41 µg/mL, respectively. Compounds 3-1 and 3-7 may be further optimized as lead compounds for new herbicides.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.