Design, Synthesis, Biological Activities and 3D-QSAR of New N,N'-Diacylhydrazines Containing 2,4-Dichlorophenoxy Moieties

Molecules

Guo-Xiang Sun¹  Zhao-Hui Sun³  Ming-Yan Yang³  Xing-Hai Liu³  Yi Ma² 

[1] School of Chemical and Biological Engineering, Yancheng Institute of Technology, Yancheng 224051, Jiangsu, China; E-Mail:;State-Key Laboratory of Elemento-Organic Chemistry, National Pesticidal Engineering Centre (Tianjin), Nankai University, Tianjin 300071, China; E-Mail:;College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, China; E-Mails:

关键词: N;    -diacylhydrazines"'>N'-diacylhydrazines;    herbicidal activity;    plant growth regulate activity;    synthesis;    3D-QSAR;   

DOI  :  10.3390/molecules181214876

来源: mdpi

【 摘 要 】

A series of new N,N'-diacylhydrazine derivatives were designed and synthesized. Their structures were verified by ¹H-NMR, MS and elemental analysis. The herbicidal activities and plant growth regulating activity of these N,N'-diacylhydrazines were evaluated. The herbicidal activity results showed that most of these N,N'-diacyl-hydrazines showed excellent in vivo activities against Echinochloa crus-galli, Digitaria sanguinalis, Brassica napus, Amaranthus retroflerus. Most of them exhibited higher herbicidal activities against dicotyledonous weeds than monocotyledonous weeds. To further investigate the structure-activity relationship, comparative molecular field analysis (CoMFA) was performed on the basis of herbicidal activity data. Both the steric and electronic field distributions of CoMFA are in good agreement in this work.

【 授权许可】

CC BY   
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