Italian Contributions to the Development of Continuous Glucose Monitoring Sensors for Diabetes Management

Sensors

Giovanni Sparacino²  Mattia Zanon²  Andrea Facchinetti²  Chiara Zecchin²  Alberto Maran¹ 

[1] Department of Clinical and Experimental Medicine, Metabolic Division, University of Padova, Via Giustiniani 2, 35128 Padova, Italy; E-Mail:;Department of Information Engineering, University of Padova, Via Gradenigo 6/B, 35131 Padova, Italy; E-Mails:

关键词: diabetes;    biosensors;    non-invasive sensors;    glucose-oxidase;    signal processing;    sensor calibration;    model;    time-series;   

DOI  :  10.3390/s121013753

来源: mdpi

【 摘 要 】

Monitoring glucose concentration in the blood is essential in the therapy of diabetes, a pathology which affects about 350 million people around the World (three million in Italy), causes more than four million deaths per year and consumes a significant portion of the budget of national health systems (10% in Italy). In the last 15 years, several sensors with different degree of invasiveness have been proposed to monitor glycemia in a quasi-continuous way (up to 1 sample/min rate) for relatively long intervals (up to 7 consecutive days). These continuous glucose monitoring (CGM) sensors have opened new scenarios to assess, off-line, the effectiveness of individual patient therapeutic plans from the retrospective analysis of glucose time-series, but have also stimulated the development of innovative on-line applications, such as hypo/hyper-glycemia alert systems and artificial pancreas closed-loop control algorithms. In this review, we illustrate some significant Italian contributions, both from industry and academia, to the growth of the CGM sensors research area. In particular, technological, algorithmic and clinical developments performed in Italy will be discussed and put in relation with the advances obtained in the field in the wider international research community.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.