Molecules | |
The Kabachnik–Fields Reaction: Mechanism and Synthetic Use | |
György Keglevich1  | |
[1] Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, Hungary | |
关键词: Kabachnik–Fields reaction; α-aminophosphonates; reaction pathway; environmentally friendly; microwave; solventless; | |
DOI : 10.3390/molecules171112821 | |
来源: mdpi | |
【 摘 要 】
The Kabachnik–Fields (phospha-Mannich) reaction involving the condensation of primary or secondary amines, oxo compounds (aldehydes and ketones) and >P(O)H species, especially dialkyl phosphites, represents a good choice for the synthesis of α-aminophosphonates that are of significant importance due to their biological activity. In general, these three-component reactions may take place via an imine or an α-hydroxy-phosphonate intermediate. The monitoring of a few Kabachnik–Fields reactions by
【 授权许可】
CC BY
© 2012 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202003190040881ZK.pdf | 303KB | download |