Modern Micro and Nanoparticle-Based Imaging Techniques

Sensors

Marketa Ryvolova²  Jana Chomoucka²  Jana Drbohlavova²  Pavel Kopel²  Petr Babula²  David Hynek²  Vojtech Adam²  Tomas Eckschlager³  Jaromir Hubalek²  Marie Stiborova¹  Jozef Kaiser² 

[1] Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, CZ 128 40 Prague 2, Czech Republic; E-Mail:;Central European Institute of Technology, Brno University of Technology, Technicka 3058/10, CZ-616 00 Brno, Czech Republic; E-Mails:;Department of Paediatric Haematology and Oncology, 2nd Faculty of Medicine Charles University in Prague and University Hospital Motol, Prague, Czech Republic; E-Mail:

关键词: imaging techniques;    nanoparticles;    fluorescence;    magnetic resonance imaging;   

DOI  :  10.3390/s121114792

来源: mdpi

【 摘 要 】

The requirements for early diagnostics as well as effective treatment of insidious diseases such as cancer constantly increase the pressure on development of efficient and reliable methods for targeted drug/gene delivery as well as imaging of the treatment success/failure. One of the most recent approaches covering both the drug delivery as well as the imaging aspects is benefitting from the unique properties of nanomaterials. Therefore a new field called nanomedicine is attracting continuously growing attention. Nanoparticles, including fluorescent semiconductor nanocrystals (quantum dots) and magnetic nanoparticles, have proven their excellent properties for in vivo imaging techniques in a number of modalities such as magnetic resonance and fluorescence imaging, respectively. In this article, we review the main properties and applications of nanoparticles in various in vitro imaging techniques, including microscopy and/or laser breakdown spectroscopy and in vivo methods such as magnetic resonance imaging and/or fluorescence-based imaging. Moreover the advantages of the drug delivery performed by nanocarriers such as iron oxides, gold, biodegradable polymers, dendrimers, lipid based carriers such as liposomes or micelles are also highlighted.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.