The Role of Vascular Endothelial Growth Factor A Polymorphisms in Breast Cancer

International Journal of Molecular Sciences

Doonyapat Sa-nguanraksa¹ 

[1] Division of Head-Neck and Breast Surgery, Department of Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand; E-Mail

关键词: angiogenesis;    breast cancer;    polymorphism;    vascular endothelial growth factor;   

DOI  :  10.3390/ijms131114845

来源: mdpi

【 摘 要 】

Breast cancer is the most common cancer in females and the leading cause of cancer death in women worldwide. Angiogenesis, the formation of new blood vessels, plays an important role in the development and progression of breast cancer. Vascular endothelial growth factor A (VEGFA), the key modulator of angiogenesis, is highly expressed in cancer tissue and correlates with its more aggressive features. Polymorphisms of VEGFA alter the levels of expression and subsequently influence the susceptibility and aggressiveness of breast cancer. Assessment of VEGFA polymorphisms may be used for the identification of patients suitable for anti-VEGFA therapy.

【 授权许可】

CC BY   
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.