An Efficient One-Pot Synthesis of Pyrano[3,2-c]quinolin-2,5-dione Derivatives Catalyzed by L-Proline

Molecules

Songlei Zhu²  Jing Wang¹  Zhou Xu¹ 

[1] Department of Chemistry, Xuzhou Medical College, Xuzhou 221004, China;Key Laboratory of Biological Cancer Therapy of Jiangsu Province, Xuzhou Medical College, Xuzhou 221004, China

关键词: pyrano[3;    2-c]quinolin-2;    5(6H)-dione;    multi-component reaction;    L-proline;   

DOI  :  10.3390/molecules171213856

来源: mdpi

【 摘 要 】

A series of 4-aryl-6-methyl-3,4-dihydro-2H-pyrano[3,2-c]quinolin-2,5(6H)-diones were synthesized via the three-component reactions of aromatic aldehydes, 4-hydroxy-1-methylquinolin-2(1H)-one, and Meldrum’s acid catalyzed by L-proline. The structures of the products were identified by spectroscopic analysis. A mechanism for this three-component reaction catalyzed by L-proline was proposed.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.