Brain Metastases from Colorectal Cancer: Microenvironment and Molecular Mechanisms

International Journal of Molecular Sciences

Yi-Wen Zang¹  Xiao-Dong Gu¹  Jian-Bin Xiang² 

[1] Department of General Surgery, Huashan Hospital, Fudan University, 12 Middle Wulumiqi Road, Shanghai 200040, China;

关键词: colorectal cancer;    brain metastasis;    microenvironment;   

DOI  :  10.3390/ijms131215784

来源: mdpi

【 摘 要 】

Colorectal cancer is one of the most common digestive tract malignancies in the world. Owing to the newer and more effective systemic therapies, the life of colorectal cancer patients can be remarkably prolonged, and the incidence of brain metastases is increasing. However, little is known about the underlying mechanisms of brain metastasis from colorectal cancer. Here we review the tumor microenvironment and metastasis associated molecules in brain metastases from colorectal cancer. A further understanding of these mechanisms will help us to propose better strategies for colorectal cancer patients with brain metastasis and improve their life quality.

【 授权许可】

CC BY   
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.