Isolation, Characterization, and Bioactivity Evaluation of 3-((6-Methylpyrazin-2-yl)methyl)-1H-indole, a New Alkaloid from a Deep-Sea-Derived Actinomycete Serinicoccus profundi sp. nov.

Marine Drugs

Xian-Wen Yang²  Gai-Yun Zhang³  Jian-Xi Ying³  Bing Yang¹  Xue-Feng Zhou¹  Andre Steinmetz²  Yong-Hong Liu¹ 

[1] Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China; E-Mails:;Luxembourg Public Research Center for Health (CRP-SANTE), 84 Val Fleuri, Luxembourg L-1526, Luxembourg; E-Mails:;Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration, Xiamen 361005, China; E-Mails:

关键词: deep-sea sediment;    actinomycete;    Serinicoccus profundi sp. nov.;    alkaloid;    antibacterial activity;    cytotoxicity;   

DOI  :  10.3390/md11010033

来源: mdpi

【 摘 要 】

One new alkaloid, 3-((6-methylpyrazin-2-yl)methyl)-1H-indole (1) was obtained from the deep-sea actinomycete Serinicoccus profundi sp. nov., along with five known compounds (2–6). Their structures were determined on the basis of detailed analysis of the 1D and 2D NMR as well as MS data. The new indole alkaloid displayed weak antimicrobial activity against Staphylococcus aureus ATCC 25923 with an MIC value of 96 μg/mL. It showed no cytotoxicity on a normal human liver cell line (BEL7402) and a human liver tumor cell line (HL-7702).

【 授权许可】

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