Two New Cytotoxic Indole Alkaloids from a Deep-Sea Sediment Derived Metagenomic Clone

Marine Drugs

Xia Yan²  Xi-Xiang Tang¹  Lin Chen²  Zhi-Wei Yi¹  Mei-Juan Fang²  Zhen Wu² 

[1] Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography State Oceanic Administration, Xiamen 361005, China; E-Mails:;Key Laboratory for Chemical Biology of Fujian Province, School of Pharmaceutical Sciences, Xiamen University, South Xiang-An Road, Xiamen 361102, China; E-Mails:

关键词: deep-sea sediment;    metagenomic clone;    indole alkaloids;    metagenetriindole A;    metagenebiindole A;    cytotoxicity;   

DOI  :  10.3390/md12042156

来源: mdpi

【 摘 要 】

Two new indole alkaloids, metagenetriindole A (1) and metagenebiindole A (2), were identified from deep-sea sediment metagenomic clone derived Escherichia coli fermentation broth. The structures of new compounds were elucidated by spectroscopic methods. The two new indole alkaloids demonstrated moderately cytotoxic activity against CNE2, Bel7402 and HT1080 cancer cell lines in vitro.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.