International Journal of Molecular Sciences | |
Identification of Recurrence Related microRNAs in Hepatocellular Carcinoma after Surgical Resection | |
Zhen Yang2  Ruoyu Miao1  Guangbing Li2  Yan Wu3  Simon C. Robson3  Xiaobo Yang2  Yi Zhao1  Haitao Zhao2  | |
[1] Bioinformatics Research Group, Center for Advanced Computing Technology Research, Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100190, China; E-Mails:;Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing 100730, China; E-Mails:;Liver Center and Transplant Institute, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215,USA; E-Mails: | |
关键词: microRNA; expression; hepatocellular carcinoma; recurrence; | |
DOI : 10.3390/ijms14011105 | |
来源: mdpi | |
【 摘 要 】
Hepatocellular carcinoma (HCC) is one of the most aggressive human cancers with a high frequency of post-surgical recurrence. It is very critical to diagnose HCC recurrence at an early stage for a better therapeutic treatment. In this study, we examined the microRNA (miRNA) expression profiling in tumor tissues obtained from early and late recurrent HCC patients post-resection, using a microarray assay. A total of 32 miRNAs were identified to be differentially expressed during the progression of recurrence. Among these, 16 miRNAs were upregulated and 16 were downregulated. In addition, this miRNA expression signature was further validated by quantitative real-time polymerase chain reaction (qRT-PCR) analysis. Moreover, functional annotation of predicted target genes of these recurrent HCC-related miRNAs indicates that multiple biological pathways (
【 授权许可】
CC BY
© 2013 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.
【 预 览 】
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