Use of an Ophthalmic Viscosurgical Device for Experimental Retinal Detachment in Rabbit Eyes

Journal of Functional Biomaterials

Akira Hirata¹  Soichiro Yamamoto² 

[1] Department of Ophthalmology, Faculty of Medicine, Saga University, 5-1-1, Nabeshima, Saga 849-8501, Japan;

关键词: OVD;    optical coherence tomography;    retinal adhesive;    retinal detachment;    retinal glue;    vitrectomy;   

DOI  :  10.3390/jfb4010006

来源: mdpi

【 摘 要 】

To investigate the temporary tamponade effects of an ophthalmic viscosurgical device (OVD) for experimental retinal tears, we performed vitrectomy in four rabbit eyes and created a posterior vitreous detachment and artificial retinal tear to produce retinal detachment. The retina was flattened with liquid perfluorocarbon (PFC), the area peripheral to the tear was photocoagulated, an OVD was applied to the retinal tear surface below the PFC and the PFC was removed by aspiration. In the control group, PFC was removed without application of OVD. At one, three and seven days postoperatively, funduscopy and optical coherence tomography (OCT) were performed to examine the sealing process of the retinal tear. In OVD-treated eyes, the OVD remained on the retinal surface, and the retinal tear was patched for ≥ 3 days postoperatively. By seven days postoperatively, the OVD on the retinal surface had disappeared, and the retina was reattached. In control eyes, the edge of the retinal tear was rolled, and retinal detachment persisted. In OVD-treated eyes, the border of the retinal tear was indistinct, and the defect area was significantly decreased. These results show that application of an OVD effectively seals retinal tears and eliminates retinal detachments.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.