Absolute Configuration of the New 3-epi-cladocroic Acid from the Mediterranean Sponge Haliclona fulva

Metabolites

Grégory Genta-Jouve¹ 

[1] Nice Institute of Chemistry UMR 7272 CNRS-PCRE, University of Nice-Sophia Antipolis, Parc Valrose, 06108 Nice, France; E-Mail

关键词: natural products;    electronic circular dichroism;    mass spectroscopy;    cladocroic acid;    sponge;   

DOI  :  10.3390/metabo3010024

来源: mdpi

【 摘 要 】

The marine sponge Haliclona fulva (previously described as Reniera fulva) is widespread in the Mediterranean Sea. The chemical study of the sponge led to the isolation and identification of a new compound: 3-epi-cladocroic acid (1) alongside the previously reported cladocroic acid (2) and some other known compounds previously isolated. The structure was fully determined on the basis of extensive analysis by 1D and 2D NMR, as well as GC-MS/MS. The absolute configuration was determined by comparison of the experimental electronic circular dichroism (ECD) spectra with theoretically calculated spectra; these results may be extended to other asymetric cyclopropane carboxylic acids.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.