Extractive from Hypericum ascyron L promotes serotonergic neuronal differentiation in vitro - ScienceDirect

Stem Cell Research

Wenhao Zhang^1¹  Qian Gao^1,2²  Haisong Wang^1³ 

[1]Department of Gynecology and Obstetrics, Peking University Third Hospital, Beijing 100191, China^2

[2]Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University, Tianjin 300070, China^3

[3]State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin 300350, China^1

关键词: Cell differentiation;    Chemical modification;    Depression;    Chinese medicine;    Neural differentiation;    Serotonergic neuron;    ESCs;    embryonic stem cells;    5-HT;    5-hydroxytryptamine;    MPLC;    medium pressure liquid chromatography;    HPLC;    high-performance liquid chromatography;    NMR;    nuclear magnetic resonance;    ECD;    electronic circular dichroism;    TDDFT;    time-dependent density functional theory;    EB;    embryoid body;    FACS;    fluorescence-activated cell sorting;    NPCs;    neural precursor cells;    RA;    retinoic acid;    mESCs;    mouse embryonic stem cells;    hESCs;    human embryonic stem cells;    NSC;    neural stem cell;    FGF4;    fibroblast growth factor-4;    SHH;    sonic hedgehog;    bFGF;    basic fibroblast growth factor;    FGF8;    fibroblast growth factor-8;    BDNF;    brain-derived neurotrophic factor;    SERT;    serotonin transporter;    TLC;    thin layer chromatography;    ODS;    octadecylsilyl;    LIF;    leukemia inhibitory factor;    TCA;    trichloroacetic acid;    MS;    mass spectrometer;   

DOI  :  10.1016/j.scr.2018.07.003

学科分类：生物科学（综合）

来源: Elsevier

【 摘 要 】

BackgroundPlant natural products have many different biological activities but the precise mechanisms underlying these activities remain largely unknown. Hypericum longistylum has long been recorded in Chinese medicine as a cure for depression and related disorders, but how it repairs neural lineages has not been addressed.

【 授权许可】

Unknown