Role of Oxidative Stress in Refractory Epilepsy: Evidence in Patients and Experimental Models

International Journal of Molecular Sciences

Noemi Cardenas-Rodriguez²  Bernardino Huerta-Gertrudis²  Liliana Rivera-Espinosa¹  Hortencia Montesinos-Correa³  Cindy Bandala⁴  Liliana Carmona-Aparicio² 

[1] Laboratory of Pharmacology, National Institute of Pediatrics, 04530, D.F., Mexico; E-Mail:;Laboratory of Neurochemistry, National Institute of Pediatrics, 04530, D.F., Mexico; E-Mails:;Department of Endocrinology, National Institute of Pediatrics, 04530, D.F., Mexico; E-Mail:;Unit of Support to Research, National Institute of Rehabilitation, 14389, D.F., Mexico; E-Mail:

关键词: oxidative stress;    free radicals;    refractory epilepsy;    pharmacoresistant epilepsy;   

DOI  :  10.3390/ijms14011455

来源: mdpi

【 摘 要 】

Oxidative stress, a state of imbalance in the production of reactive oxygen species and nitrogen, is induced by a wide variety of factors. This biochemical state is associated with systemic diseases, and diseases affecting the central nervous system. Epilepsy is a chronic neurological disorder with refractoriness to drug therapy at about 30%. Currently, experimental evidence supports the involvement of oxidative stress in seizures, in the process of their generation, and in the mechanisms associated with refractoriness to drug therapy. Hence, the aim of this review is to present information in order to facilitate the handling of this evidence and determine the therapeutic impact of the biochemical status for this pathology.

【 授权许可】

CC BY   
© 2013 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.