Antioxidant Capacity of Two Novel Bioactive Fe(III)-Cyclophane Complexes

Molecules

Alex J. Salazar-Medina¹  Rocío Sugich-Miranda¹  Eli Teran-Cabanillas¹  Jesús Hernández¹  Gustavo A. González-Aguilar¹  Enrique Rudiño-Piñera¹  Rogerio R. Sotelo-Mundo¹ 

[1] ¹Departamento de Investigación en Polímeros y Materiales (DIPM), Universidad de Sonora, Calle Rosales y Blvd, Luis Encinas s/n, Col. Centro, PO Box 130. Hermosillo Sonora 83000, Mexico

关键词: cyclophane;    macrocycle;    iron;    biomimetic;    antioxidant;   

DOI  :  10.3390/molecules18021762

来源: mdpi

【 摘 要 】

The cyclophanes 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10, 24,27,30,33-octaaza-17,40-dioxa[10.1.10.1]paracyclophane (PO) and 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10,24,27,30,33-octaaza[10.1.10.1]paracyclophane (PC) were coordinated with iron to form cationic binuclear Fe(III) Fe₂PO and Fe₂PC complexes, respectively. Their antioxidant capacity, superoxide dismutase and peroxidase mimetic activity, as well as their toxicity toward peripheral blood mononuclear cells (PBMCs) were evaluated. Both Fe₂PO and Fe₂PC are interesting biomimetics with antioxidant capacity similar to that of ascorbic acid that prevent mortality in cultured PBMCs, with the potential to have bioactive and protective functions in disease animal models.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.