Novel One-Pot Green Synthesis of Indolizines Biocatalysed by Candida antarctica Lipases

Marine Drugs

Rodica Mihaela Dinica²  Bianca Furdui²  Ioana Otilia Ghinea³  Gabriela Bahrim³  Simon Bonte¹ 

[1] Département Pharmacochimie Moléculaire, UMR 5063 & FR 2607, CNRS/Université de Grenoble, 38041 Grenoble cedex 9, France; E-Mail:;Department of Chemistry, Physics and Environment, Faculty of Science and Environment, “Dunarea de Jos” University of Galati, 111 Domneasca Street, Galati 800201, Romania; E-Mail:;Department of Food Science, Food Engineering and Applied Biotechnology, Faculty of Food Science and Engineering, “Dunarea de Jos” University of Galati, 111 Domneasca Street, Galati 800201, Romania; E-Mails:

关键词: indolizine;    Candida antarctica lipase;    one-pot reaction;    cycloaddition;    ylide;   

DOI  :  10.3390/md11020431

来源: mdpi

【 摘 要 】

Marine microorganisms are of considerable interest as a promising source of enzymes with unsuspected potentials as catalysts for chemical synthesis. We describe here an efficient method for one-pot indolizine synthesis that has been developed using lipase A and lipase B from Candida antarctica as biocatalysts. As showed by HPLC/MS analysis, the yield in indolizines was higher in the presence of the biocatalyst than in absence of enzyme. Lipase A, from Candida antarctica, showed high catalytic activity and selectivity for the cycloaddition reactions. When the reactions were performed under ultrasound irradiation, the Candida antarctica lipase catalyzed reactions yielded pure indolozines, in good yields and in very short time.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.