Secondary Metabolites from Sida rhombifolia L. (Malvaceae) and the Vasorelaxant Activity of Cryptolepinone

Molecules

Otemberg Souza Chaves¹  Roosevelt Albuquerque Gomes¹  Anna Cláudia de Andrade Tomaz¹  Marianne Guedes Fernandes¹  Leônidas das Gra๺s Mendes Junior¹  Maria de Fátima Agra¹  Valdir Andrade Braga¹ 

[1] id="af1-molecules-18-02769">Postgraduate Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, 58051-970, João Pessoa, PB, Braz

关键词: phytochemical study;    Sida rhombifolia L.;    Malvaceae;    cryptolepinone;    vasorelaxant activity;   

DOI  :  10.3390/molecules18032769

来源: mdpi

【 摘 要 】

The phytochemical study of Sida rhombifolia L. (Malvaceae) led to the isolation through chromatographic techniques of eleven secondary metabolites: sitosterol (1a) and stigmasterol (1b), sitosterol-3-O-β-d-glucopyranoside (2a) and stigmasterol-3-O-β-d-glucopyranoside (2b), phaeophytin A (3), 17³-ethoxypheophorbide A (4), 13²-hydroxy phaeophytin B (5), 17³-ethoxypheophorbide B (6), 5,7-dihydroxy-4'-methoxyflavone (7), cryptolepinone (8) and a salt of cryptolepine (9). Their structures were identified by ¹H- and ¹³C-NMR using one- and two-dimensional techniques. In addition, the vasorelaxant activity of cryptolepinone in rat mesenteric artery rings is reported herein for the first time.

【 授权许可】

CC BY   
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