First Chemical Constituents from Cordia exaltata Lam and Antimicrobial Activity of Two Neolignans

Molecules

Tiago Bezerra de Sá de Sousa Nogueira¹  Raquel Bezerra de Sá de Sousa Nogueira¹  Davi Antas e Silva⁴  Josean Fechine Tavares¹  Edeltrudes de Oliveira Lima¹  Fillipe de Oliveira Pereira¹  Milen Maria Magalh฾s de Souza Fernandes¹  Fernando Antônio de Medeiros³  Rosangela do Socorro Ferreira Rodrigues Sarquis³  Raimundo Braz Filho⁵  Jéssica Karina da Silva Maciel² 

[1] Postgraduate Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, João Pessoa, PB 58051-970, Brazil;Postgraduate Program in Development and Technological Innovation in Drug-Center for Health Sciences, Federal University of Paraíba, João Pessoa, PB 58051-970, Brazil;Institute for Scientific and Technological Research of Amapá, Macapá, AP 68901-025, Brazil;Department of Physiology and Pathology, Health Sciences Center, Federal University of Paraíba, João Pessoa, PB 58051-970, Brazil;Laboratório de Ciências Químicas, Universidade Estadual do Norte Fluminense Darcy Ribeiro-UFRRJ, Campos dos Goytacazes, RJ 28013-602, Brazil

关键词: phytochemical study;    Cordia exaltata Lam.;    Boraginaceae;    antimicrobial activity;   

DOI  :  10.3390/molecules180911086

来源: mdpi

【 摘 要 】

The phytochemical study of Cordia exaltata Lam. (Boraginaceae) led to the isolation, through chromatographic techniques, of nineteen secondary metabolites: 8,8'dimethyl-3,4,3',4'-dimethylenedioxy-7-oxo-2,7'cyclolignan (1), 8,8'-dimethyl-4,5-dimethoxy-3',4'-methylenodioxy-7-oxo-2,7'cyclolignan (2), sitosterol (3a), stigmasterol (3b), sitosterol-3-O-β-d-glucopyranoside (4a), stigmasterol-3-O-β-d-glucopyranoside (4b), phaeophytin A (5), 13²-hydroxyphaeophytin A (6), 17³-ethoxypheophorbide A (7), 13²-hydroxy-17³-ethoxypheophorbide A (8), m-methoxy-p-hydroxybenzaldehyde (9), (E)-7-(3,4-dihydroxyphenyl)-7-propenoic acid (10), 1-benzopyran-2-one (11), 7-hydroxy-1-benzopyran-2-one (12), 2,5-bis-(3',4'-methylenedioxiphenyl)-3,4-dimethyltetrahydrofuran (13), 3,4,5,3',5'-pentamethoxy-1'-allyl-8.O.4'-neolignan (14), 3,5,7,3',4'-pentahydroxyflavonol (15),5,7-dihydroxy-4'-methoxyflavone (16), 5,8-dihydroxy-7,4’-dimethoxyflavone (17), kaempherol 3-O-β-d-glucosyl-6''-α-L-ramnopyranoside (18) and kaempherol 3,7-di-O-α-l-ramnopyranoside (19). Their structures were identified by ¹H and ¹³C-NMR using one and two-dimensional techniques. In addition, the antimicrobial activity of compounds 1, 2, 13 and 14 against bacteria and fungi are reported here for the first time.

【 授权许可】

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