Volatiles, A Glutarimide Alkaloid and Antimicrobial Effects of Croton pullei (Euphorbiaceae)

Molecules

Rosana N. S. Peixoto³  Giselle M. S. P. Guilhon³  Maria das Gra๺s B. Zoghbi²  Isabella S. Araújo¹  Ana Paula T. Uetanabaro¹  Lourivaldo S. Santos³ 

[1] Programa de Pós-graduação em Biotecnologia, Universidade Estadual de Feira de Santana, Av. Transnordestina s/n, 44036-900, Feira de Santana-BA, Brazil; E-Mail:;Coordenação de Botânica, Museu Paraense Emílio Goeldi, CP 399, 66077-901, Belém-PA, Brazil; E-Mail:;Programa de Pós-graduação em Química, Universidade Federal do Pará, Av. Augusto Corrêa 01, 66075-110, Belém-PA, Brazil; E-Mails:

关键词: Croton pullei;    essential oils;    glutarimide alkaloid;    antibacterial activity;    antifungal activity;   

DOI  :  10.3390/molecules18033195

来源: mdpi

【 摘 要 】

Abstract: Chemical investigation of Croton pullei (Euphorbiaceae) collected in the Brazilian Amazon region was revisited. The chemical composition of the essential oils of leaves and stems was analyzed by GC/MS. It was found that both the oils comprise mainly terpenes, among which linalool was the major one (24.90 and 39.72%, respectively). Phytochemical investigation of the stem methanol extract led to the isolation of a new natural product from the glutarimide alkaloid group named N-[2,6-dioxo-1-(2-phenylethyl)-3-piperidinyl]-acetamide, confirming that C. pullei is a rich source of this class of alkaloids. The hexane and methanol extracts of the stems of C. pullei showed moderate antibacterial and antifungal activity and the highest inhibition was observed when the methanol extract was tested against Staphylococcus aureus CCMB 262 and CCMB 263.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.