Molecules | |
Synthesis and Trypanocidal Activity of Novel 2,4,5-Triaryl- |
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Ramon Borges da Silva4  Vanessa Brandão Loback4  Kelly Salomão3  Solange Lisboa de Castro3  James L. Wardell1  Solange M. S. V. Wardell2  Thadeu Estevam Moreira Maramaldo Costa4  Carmen Penido4  Maria das Gras Muller de Oliveira Henriques4  Samir Aquino Carvalho4  Edson Ferreira da Silva4  | |
[1] Centro de Desenvolvimento Tecnológico em Saúde (CDTS), Fundação Oswaldo Cruz, 21040-900, Rio de Janeiro, RJ, Brazil; E-Mail:;CHEMSOL, 1 Harcourt Road, Aberdeen AB15 5NY, Scotland, UK; E-Mail:;Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, 21040-900, Rio de Janeiro, RJ, Brazil; E-Mails:;Instituto de Tecnologia em Fármacos — Farmanguinhos, Fundação Oswaldo Cruz, 21041-250, Rio de Janeiro, RJ, Brazil; E-Mails: | |
关键词:
2;
4;
5-triaryl- |
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DOI : 10.3390/molecules18033445 | |
来源: mdpi | |
【 摘 要 】
Herein, we report the design, synthesis and trypanocidal activity of some novel trisubstituted imidazole derivatives. These heterocyclic derivatives were structurally planned by exploring the concept of molecular hybridisation between two arylhydrazones derived from megazol, which has potent trypanocidal activity. The trypanocidal activity of these triarylimidazole derivatives was evaluated against infective trypomastigote forms of
【 授权许可】
CC BY
© 2013 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190037813ZK.pdf | 265KB | download |