Ubiquitinations in the Notch Signaling Pathway

International Journal of Molecular Sciences

Julien Moretti¹ 

[1] Immunology Institute, Department of Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA; E-Mail:

关键词: Notch;    ubiquitination;    deubiquitinating enzyme;    signal transduction;    trafficking;   

DOI  :  10.3390/ijms14036359

来源: mdpi

【 摘 要 】

The very conserved Notch pathway is used iteratively during development and adulthood to regulate cell fates. Notch activation relies on interactions between neighboring cells, through the binding of Notch receptors to their ligands, both transmembrane molecules. This inter-cellular contact initiates a cascade of events eventually transforming the cell surface receptor into a nuclear factor acting on the transcription of specific target genes. This review highlights how the various processes undergone by Notch receptors and ligands that regulate the pathway are linked to ubiquitination events.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.