Efficient Synthesis and Anti-Fungal Activity of Oleanolic Acid Oxime Esters

Molecules

Hanqing Zhao²  Minjie Zhou²  Lifeng Duan²  Wei Wang²  Jianjun Zhang¹  Daoquan Wang² 

[1] id="af1-molecules-18-03615">Department of Applied Chemistry, China Agricultural University, Beijing 100193, Chi

关键词: oleanolic acid;    oxime ester;    glucosamine-6-phosphate synthase;    anti-fungal activity;   

DOI  :  10.3390/molecules18033615

来源: mdpi

【 摘 要 】

In order to develop potential glucosamine-6-phosphate synthase inhibitors and anti-fungal agents, twenty five oleanolic acid oxime esters were synthesized in an efficient way. The structures of the new compounds were confirmed by MS, HRMS, ¹H-NMR and ¹³C-NMR. Preliminary studies based on means of the Elson-Morgan method indicated that many compounds exhibited some inhibitory activity of glucosamine-6-phosphate synthase (GlmS), and the original fungicidal activities results showed that some of the compounds exhibited good fungicidal activities towards Sclerotinia sclerotiorum (Lib.) de Bary, Rhizoctonia solani Kuhn and Botrytis cinerea Pers at the concentration of 50 µg/mL. These compounds would thus merit further study and development as antifungal agents.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.