International Journal of Molecular Sciences | |
Quantification of Maternal Serum Cell-Free Fetal DNA in Early-Onset Preeclampsia | |
Hong Yu2  Yanting Shen2  Qinyu Ge1  Youji He3  Dongyan Qiao2  Mulan Ren2  | |
[1] State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China; E-Mail:;Department of Obstetrics and Gynecology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China; E-Mails:;Department of Microbiology and Immunology, Medical School, Southeast University, Nanjing 210009, China; E-Mail: | |
关键词: preeclampsia; cell-free fetal DNA; HCG; | |
DOI : 10.3390/ijms14047571 | |
来源: mdpi | |
【 摘 要 】
The aim of this study was to determine whether the increased serum cell-free fetal DNA (cffDNA) level of gravidas developed into early-onset preeclampsia (EOPE) subsequently in the early second trimesters is related to prenatal screening markers. Serum was collected from 1011 gravidas. The level of cffDNA and prenatal screening markers were analyzed in 20 cases with EOPE and 20 controls. All fetuses were male. The maternal serum cffDNA level was assessed by amplification of the Y chromosome specific gene. Correlations between the variables were examined. (Logged) cffDNA in EOPE (median, 3.08; interquartile range, 2.93–3.68) was higher than controls (median, 1.79; interquartile range, 1.46–2.53). The increased level of (logged) cffDNA was correlated significantly with the increased human chorionic gonadotropin (HCG) level (
【 授权许可】
CC BY
© 2013 by the authors; licensee MDPI, Basel, Switzerland
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