Combined Screening for Early Detection of Pre-Eclampsia

International Journal of Molecular Sciences

Hee Jin Park¹  Sung Shin Shim¹  Dong Hyun Cha² 

[1] Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul 135-081, Korea;

关键词: pre-eclampsia;    early prediction;    maternal risk factors;    mean maternal arterial pressure;    ultrasound parameters;    biomarker;    pregnancy-associated plasma protein-A (PAPP-A);    cell-free fetal DNA;   

DOI  :  10.3390/ijms160817952

来源: mdpi

【 摘 要 】

Although the precise pathophysiology of pre-eclampsia remains unknown, this condition continues to be a major cause of maternal and fetal mortality. Early prediction of pre-eclampsia would allow for timely initiation of preventive therapy. A combination of biophysical and biochemical markers are superior to other tests for early prediction of the development of pre-eclampsia. Apart from the use of parameters in first-trimester aneuploidy screening, cell-free fetal DNA quantification is emerging as a promising marker for prediction of pre-eclampsia. This article reviews the current research of the most important strategies for prediction of pre-eclampsia, including the use of maternal risk factors, mean maternal arterial pressure, ultrasound parameters, and biomarkers.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.