International Journal of Molecular Sciences | |
Combined Screening for Early Detection of Pre-Eclampsia | |
Hee Jin Park1  Sung Shin Shim1  Dong Hyun Cha2  | |
[1] Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul 135-081, Korea; | |
关键词: pre-eclampsia; early prediction; maternal risk factors; mean maternal arterial pressure; ultrasound parameters; biomarker; pregnancy-associated plasma protein-A (PAPP-A); cell-free fetal DNA; | |
DOI : 10.3390/ijms160817952 | |
来源: mdpi | |
【 摘 要 】
Although the precise pathophysiology of pre-eclampsia remains unknown, this condition continues to be a major cause of maternal and fetal mortality. Early prediction of pre-eclampsia would allow for timely initiation of preventive therapy. A combination of biophysical and biochemical markers are superior to other tests for early prediction of the development of pre-eclampsia. Apart from the use of parameters in first-trimester aneuploidy screening, cell-free fetal DNA quantification is emerging as a promising marker for prediction of pre-eclampsia. This article reviews the current research of the most important strategies for prediction of pre-eclampsia, including the use of maternal risk factors, mean maternal arterial pressure, ultrasound parameters, and biomarkers.
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190008515ZK.pdf | 704KB | download |