Oxidative Stress in Complex Regional Pain Syndrome (CRPS): No Systemically Elevated Levels of Malondialdehyde, F2-Isoprostanes and 8OHdG in a Selected Sample of Patients

International Journal of Molecular Sciences

Sigrid G. L. Fischer¹  Roberto S. G. M. Perez¹  Jan Nouta²  Wouter W. A. Zuurmond¹ 

[1] Department of Anesthesiology, VU University Medical Center, 6F002, De Boelelaan 1117, 1081HV Amsterdam, The Netherlands; E-Mail:;Department of Clinical Chemistry, VU University Medical Center, De Boelelaan 1117, 1081HV Amsterdam, The Netherlands; E-Mails:

关键词: CRPS;    oxidative stress;    inflammation;    MDA;    F2-isoprostanes;    8OHdG;   

DOI  :  10.3390/ijms14047784

来源: mdpi

【 摘 要 】

Exaggerated inflammation and oxidative stress are involved in the pathogenesis of Complex Regional Pain Syndrome (CRPS). However, studies assessing markers for oxidative stress in CRPS patients are limited. In this study, markers for lipid peroxidation (malondialdehyde and F2-isoprostanes) and DNA damage (8-hydroxy-2-deoxyguanosine) were measured in nine patients (mean age 50.1 ± 17.1 years) with short term CRPS-1 (median 3 months) and nine age and sex matched healthy volunteers (mean age 49.3 ± 16.8 years) to assess and compare the level of oxidative stress. No differences were found in plasma between CRPS patients and healthy volunteers for malondialdehyde (5.2 ± 0.9 μmol/L vs. 5.4 ± 0.5 μmol/L) F2-isoprostanes (83.9 ± 18.7 pg/mL vs. 80.5 ± 12.3 pg/mL) and 8-hydroxy-2-deoxyguanosine (92.6 ± 25.5 pmol/L vs. 86.9 ± 19.0 pmol/L). Likewise, in urine, no differences were observed between CRPS patients and healthy volunteers for F2-isoprostanes (117 ng/mmol, IQR 54.5–124.3 vs. 85 ng/mmol, IQR 55.5–110) and 8-hydroxy-2-deoxyguanosine (1.4 ± 0.7 nmol/mmol vs. 1.4 ± 0.5 nmol/mmol). Our data show no elevation of systemic markers of oxidative stress in CRPS patients compared to matched healthy volunteers. Future research should focus on local sampling methods of oxidative stress with adequate patient selection based on CRPS phenotype and lifestyle.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland