Antinociceptive Activity of Stephanolepis hispidus Skin Aqueous Extract Depends Partly on Opioid System Activation

Marine Drugs

Vinicius Carvalho²  Lohengrin Fernandes³  Taline Conde¹  Helena Zamith¹  Ronald Silva¹  Andrea Surrage⁴  Valber Frutuoso⁴  Hugo Castro-Faria-Neto⁴ 

[1] Laboratory of Pharmacology, INCQS, Fiocruz, Rio de Janeiro-RJ, 21045-900, Brazil; E-Mails:;Laboratory of Inflammation, IOC, Fiocruz, Rio de Janeiro-RJ, 21045-900, Brazil;Division of Marine Ecosystems, Department of Oceanography, IEAPM, Arraial do Cabo-RJ, 28930-000, Brazil; E-Mail:;Laboratory of Immunopharmacology, IOC, Fiocruz, Rio de Janeiro-RJ, 21045-900, Brazil; E-Mails:

关键词: Stephanolepis hispidus;    fish skin;    antinociceptive;    peixe-porco;    marine products;   

DOI  :  10.3390/md11041221

来源: mdpi

【 摘 要 】

Stephanolepis hispidus is one of the most common filefish species in Brazil. Its skin is traditionally used as a complementary treatment for inflammatory disorders. However, there are very few studies on chemical and pharmacological properties using the skin of this fish. This study was undertaken in order to investigate the effect of aqueous crude extract of S. hispidus skin (SAE) in different nociception models. Here, we report that intraperitoneal administration of SAE inhibited the abdominal constrictions induced by acetic acid in mice. In addition to the effect seen in the abdominal constriction model, SAE was also able to inhibit the hyperalgesia induced by carrageenan and prostaglandin E2 (PGE2) in mice. This potent antinociceptive effect was observed in the hot plate model too, but not in tail-flick test. Naloxone, an opioid receptor antagonist, was able to block the antinociceptive effect of SAE in the abdominal constriction and hot plate models. In addition, SAE did not present cytotoxic or genotoxic effect in human peripheral blood cells. Our results suggest that aqueous crude extract from S. hispidus skin has antinociceptive activity in close relationship with the partial activation of opioid receptors in the nervous system. Moreover, aqueous crude extract from S. hispidus skin does not present toxicity and is therefore endowed with the potential for pharmacological control of pain.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.