Effect of Low Dose of Fumonisins on Pig Health: Immune Status, Intestinal Microbiota and Sensitivity to Salmonella

Toxins

Christine Burel²  Mael Tanguy²  Philippe Guerre¹  Eric Boilletot²  Roland Cariolet²  Marilyne Queguiner²  Gilbert Postollec²  Philippe Pinton³  Gilles Salvat²  Isabelle P. Oswald³ 

[1] Ecole Nationale Vétérinaire de Toulouse, Unité de mycotoxicologie, 23 chemin des Capelles, 31076 Toulouse, France; E-Mail:;ANSES, Ploufragan-Plouzané Laboratory, BP 53, 22440 Ploufragan, France; E-Mails:;INRA, UMR 1331 ToxAlim, Research Centre in Food Toxicology, 180, chemin de Tournefeuille, BP 93173, 31027 Toulouse Cedex 3, France; E-Mails:

关键词: pig;    mycotoxins;    fumonisins;    growth;    immune status;    intestinal microbiota;    health;    Salmonella;    co-contamination;   

DOI  :  10.3390/toxins5040841

来源: mdpi

【 摘 要 】

The objective of this study was to measure the effects of chronic exposure to fumonisins via the ingestion of feed containing naturally contaminated corn in growing pigs infected or not with Salmonella spp. This exposure to a moderate dietary concentration of fumonisins (11.8 ppm) was sufficient to induce a biological effect in pigs (Sa/So ratio), but no mortality or pathology was observed over 63 days of exposure. No mortality or related clinical signs, even in cases of inoculation with Salmonella (5 × 10⁴ CFU), were observed either. Fumonisins, at these concentrations, did not affect the ability of lymphocytes to proliferate in the presence of mitogens, but after seven days post-inoculation they led to inhibition of the ability of specific Salmonella lymphocytes to proliferate following exposure to a specific Salmonella antigen. However, the ingestion of fumonisins had no impact on Salmonella translocation or seroconversion in inoculated pigs. The inoculation of Salmonella did not affect faecal microbiota profiles, but exposure to moderate concentrations of fumonisins transiently affected the digestive microbiota balance. In cases of co-infection with fumonisins and Salmonella, the microbiota profiles were rapidly and clearly modified as early as 48 h post-Salmonella inoculation. Therefore under these experimental conditions, exposure to an average concentration of fumonisins in naturally contaminated feed had no effect on pig health but did affect the digestive microbiota balance, with Salmonella exposure amplifying this phenomenon.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.