Characterization of Clade 2.3.2.1 H5N1 Highly Pathogenic Avian Influenza Viruses Isolated from Wild Birds (Mandarin Duck and Eurasian Eagle Owl) in 2010 in Korea

Viruses

Jun-Gu Choi²  Hyun-Mi Kang²  Woo-Jin Jeon²  Kang-Seuk Choi²  Kwang-Il Kim²  Byung Min Song²  Hee-Soo Lee²  Jae-Hong Kim¹ 

[1] College of Veterinary Medicine, Seoul National University, 599 Gwanakro, Seoul, 151-742, Republic of Korea;Animal, Plant and Fisheries Quarantine and Inspection Agency, 175 Anyangro, Manangu, Anyang, Gyeonggi, 430-757, Republic of Korea; E-Mails:

关键词: H5N1;    highly pathogenic avian influenza;    clade 2.3.2.1;   

DOI  :  10.3390/v5041153

来源: mdpi

【 摘 要 】

Starting in late November 2010, the H5N1 highly pathogenic avian influenza (HPAI) virus was isolated from many types of wild ducks and raptors and was subsequently isolated from poultry in Korea. We assessed the genetic and pathogenic properties of the HPAI viruses isolated from a fecal sample from a mandarin duck and a dead Eurasian eagle owl, the most affected wild bird species during the 2010/2011 HPAI outbreak in Korea. These viruses have similar genetic backgrounds and exhibited the highest genetic similarity with recent Eurasian clade 2.3.2.1 HPAI viruses. In animal inoculation experiments, regardless of their originating hosts, the two Korean isolates produced highly pathogenic characteristics in chickens, ducks and mice without pre-adaptation. These results raise concerns about veterinary and public health. Surveillance of wild birds could provide a good early warning signal for possible HPAI infection in poultry as well as in humans.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.