Sesquiterpenoids from the Herb of Leonurus japonicus

Molecules

Liang Xiong²  Qin-Mei Zhou¹  Cheng Peng²  Xiao-Fang Xie²  Li Guo²  Xiao-Hong Li¹  Juan Liu¹  Zhao-Hua Liu³ 

[1] Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China; E-Mails:;State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, Sichuan, China; E-Mails:;Chengdu No.1 Pharmaceuticlco. Ltd., Chengdu 610031, Sichuan, China; E-Mail:

关键词: Leonurus japonicus;    sesquiterpenoids;    bioactivities;   

DOI  :  10.3390/molecules18055051

来源: mdpi

【 摘 要 】

Two new sesquiterpenoids, (−)-(1S*,2S*,3R*)-3-ethoxycupar-5-ene-1,2-diol (1) and (−)-(1S*,4S*,9S*)-1,9-epoxybisabola-2,10-diene-4-ol (2), along with six known compounds 3−8, were isolated from the EtOH extract of the herb of Leonurus japonicus. Their structures were elucidated by physical and spectroscopic analysis. In the in vitro assays, compounds 7 and 8 showed obvious antibacterial activity against several bacteria strains, while compound 3 significantly inhibited abnormal increase of platelet aggregation induced by ADP.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.