From Waste to Healing Biopolymers: Biomedical Applications of Bio-Collagenic Materials Extracted from Industrial Leather Residues in Wound Healing

Materials

Mercedes Catalina²  Jaume Cot²  Miquel Borras²  Joaquín de Lapuente²  Javier González²  Alina M. Balu¹ 

[1] Department of Organic Chemistry, University of Córdoba, Campus de Rabanales, Edif. Marie Curie, Ctra. Nnal IV-A, Km 396, Córdoba E14014, Spain; E-Mails:;Institute of Advanced Chemistry of Catalonia, IQAC, CSIC, C/Jordi Girona 18-26, Barcelona 08034, Spain; E-Mails:

关键词: bio-collagen;    leather waste valorisation;    wound healing;    tissue regeneration;   

DOI  :  10.3390/ma6051599

来源: mdpi

【 摘 要 】

The biomedical properties of a porous bio-collagenic polymer extracted from leather industrial waste residues have been investigated in wound healing and tissue regeneration in induced wounds in rats. Application of the pure undiluted bio-collagen to induced wounds in rats dramatically improved its healing after 7 days in terms of collagen production and wound filling as well as in the migration and differentiation of keratinocytes. The formulation tested was found to be three times more effective than the commercial reference product Catrix^® (Heal Progress (HP): 8 ± 1.55 vs. 2.33 ± 0.52, p < 0.001; Formation of Collagen (FC): 7.5 ± 1.05 vs. 2.17 ± 0.75, p < 0.001; Regeneration of Epidermis (RE): 13.33 ± 5.11 vs. 5 ± 5.48, p < 0.05).

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.