MicroRNAs and Molecular Mechanisms of Neurodegeneration

Genes

Ilaria Bicchi¹  Francesco Morena¹  Simona Montesano²  Mario Polidoro² 

[1]Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06126 Perugia, Italy

关键词: miRNAs;    Alzheimer’s disease;    Parkinson’s disease;    Huntington’s disease;    Amyotrophic Lateral Sclerosis;    Lysosomal Storage Disorders;   

DOI  :  10.3390/genes4020244

来源: mdpi

【 摘 要 】

During the last few years microRNAs (miRNAs) have emerged as key mediators of post-transcriptional and epigenetic regulation of gene expression. MiRNAs targets, identified through gene expression profiling and studies in animal models, depict a scenario where miRNAs are fine-tuning metabolic pathways and genetic networks in both plants and animals. MiRNAs have shown to be differentially expressed in brain areas and alterations of miRNAs homeostasis have been recently correlated to pathological conditions of the nervous system, such as cancer and neurodegeneration. Here, we review and discuss the most recent insights into the involvement of miRNAs in the neurodegenerative mechanisms and their correlation with significant neurodegenerative disorders.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.