Phenolic Glucosides from Dendrobium aurantiacum var. denneanum and Their Bioactivities

Molecules

Liang Xiong²  Zhi-Xing Cao²  Cheng Peng²  Xiao-Hong Li¹  Xiao-Fang Xie²  Ting-Mo Zhang¹  Qin-Mei Zhou¹  Lian Yang¹ 

[1] Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China; E-Mails:;State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, Sichuan, China; E-Mails:

关键词: Dendrobium aurantiacum var. denneanum;    lignan glucosides;    phenylpropanoid glycosides;    bioactivities;   

DOI  :  10.3390/molecules18066153

来源: mdpi

【 摘 要 】

A new 8,4'-oxyneolignane glucoside 1 has been isolated from the stems of Dendrobium aurantiacum var. denneanum together with six known phenolic glucosides 2−7. The structure of the new compound, including its absolute configuration, was determined by spectroscopic and chemical methods as (−)-(7S,8R,7'E)-4-hydroxy-3,3',5,5'-tetramethoxy-8,4'-oxyneolign-7'-ene-7,9,9'-triol 7,9'-bis-O-β-D-glucopyranoside (1). In the in vitro assays, compound 1 and (−)-syringaresinol-4,4'-bis-O-β-D-glucopyranoside (2) showed evident activity against glutamate-induced neurotoxicity in PC12 cells. Shashenoside I (4) showed a selective cytotoxic activity with the IC₅₀ value of 4.17 μM against the acute myeloid leukemia cell line MV4-11, while it was inactive against 10 other human tumor cell lines.

【 授权许可】

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