Practical Aspects and Mechanism of Asymmetric Hydrogenation with Chiral Half-Sandwich Complexes

Molecules

Jiří Vผlavík¹  Petr Šot¹  Beáta Vilhanová¹  Jan Pecháპk¹  Marek Kuzma² 

[1] Department of Organic Technology, Institute of Chemical Technology, Technická 5, CZ-166 28 Prague, Czech Republic;Laboratory of Molecular Structure Characterization, Institute of Microbiology, v.v.i., Academy of Sciences of the Czech Republic, Vídeňská 1083, CZ-142 20 Prague, Czech Republic

关键词: asymmetric hydrogenation;    ruthenium;    reaction conditions;    mechanism;    imine;   

DOI  :  10.3390/molecules18066804

来源: mdpi

【 摘 要 】

This review is oriented toward the asymmetric transfer hydrogenation (ATH) of imines regarding mostly fundamental, yet important topics from the practical point of view. Development of analytical methods for the monitoring of ATH (i.e., kinetics and stereoselectivity) belongs to those topics, as well as studies on the influence of reaction conditions and structural variations on the reaction performance. The second part is devoted to the reaction mechanism with the emphasis on imine ATH and catalyst behaviour under acidic conditions. The review also addresses the asymmetric hydrogenation (AH) of ketones and imines using molecular hydrogen and the application of ATH in pharmaceutical projects. The contributions of our group to each area are included.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.