Autophagy in Prostate Cancer and Androgen Suppression Therapy

International Journal of Molecular Sciences

Elio Ziparo¹  Simonetta Petrungaro¹  Elettra Sara Marini¹  Donatella Starace¹  Silvia Conti¹  Antonio Facchiano²  Antonio Filippini¹ 

[1] Institute Pasteur Fondazione Cenci Bolognetti, Department of Anatomy, Histology, Forensic Medicine and Orthopaedics (DAHFMO), Section of Histology & Medical Embryology, Sapienza University of Rome, Rome 00161, Italy; E-Mails:;Laboratory of Applied Dermatology, Istituto Dermopatico dell’Immacolata, IDI-IRCCS, Rome 00167, Italy; E-Mail:

关键词: autophagy;    apoptosis;    prostate cancer;    androgen deprivation therapy;   

DOI  :  10.3390/ijms140612090

来源: mdpi

【 摘 要 】

The role of autophagy is known to be highly complex and context-dependent, leading to both cancer suppression and progression in several tumors including melanoma, breast and prostate cancer. In the present review, recent advances in an understanding of the involvement of autophagy in prostate cancer treatment are described. The regulatory effects of androgens on prostate cancer cell autophagy are particularly discussed in order to highlight the effects of autophagy modulation during androgen deprivation. A critical evaluation of the studies examined in the present review suggests the attractive possibility of autophagy inhibition combined with hormonal therapy as a promising approach for prostate cancer treatment.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland