Histone Deacetylases in Herpesvirus Replication and Virus-Stimulated Host Defense

Viruses

Amanda J. Guise¹  Hanna G. Budayeva¹  Benjamin A. Diner¹ 

[1] Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544, USA;

关键词: herpesvirus;    HDAC;    IFI16;    acetylation;    NF-κB;    p53;    proteomics;    metabolomics;    chemoproteomics;   

DOI  :  10.3390/v5071607

来源: mdpi

【 摘 要 】

Emerging evidence highlights a critical role for protein acetylation during herpesvirus infection. As prominent modulators of protein acetylation, histone deacetylases (HDACs) are essential transcriptional and epigenetic regulators. Not surprisingly, viruses have evolved a wide array of mechanisms to subvert HDAC functions. Here, we review the mechanisms underlying HDAC regulation during herpesvirus infection. We next discuss the roles of acetylation in host defense against herpesvirus infection. Finally, we provide a perspective on the contribution of current mass spectrometry-based “omic” technologies to infectious disease research, offering a systems biology view of infection.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.