Marine Drugs | |
Induction of Apoptosis by Fucoidan in Human Leukemia U937 Cells through Activation of p38 MAPK and Modulation of Bcl-2 Family | |
Hyun Soo Park4  Hye Jin Hwang5  Gi-Young Kim1  Hee-Jae Cha2  Wun-Jae Kim3  Nam Deuk Kim4  Young Hyun Yoo6  | |
[1] Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Korea; E-Mail:;Departments of Parasitology and Genetics, Kosin University College of Medicine, Busan 602-702, Korea; E-Mail:;Department of Urology, Chungbuk National University College of Medicine, Cheongju 361-763, Korea; E-Mail:;Department of Pharmacy, Pusan National University, Busan 609-735, Korea; E-Mails:;Department of Food and Nutrition, Dongeui University, Busan 614-714, Korea; E-Mail:;Department of Anatomy and Cell Biology, College of Medicine, Dong-A University, Busan 602-714, Korea | |
关键词: fucoidan; leukemic cells; apoptosis; p38 MAPK; Bcl-2; | |
DOI : 10.3390/md11072347 | |
来源: mdpi | |
【 摘 要 】
The present study investigated possible mechanisms on the apoptosis induction of human leukemic cells by fucoidan, a sulfated polysaccharide found in marine algae. Fucoidan treatment of cells resulted in inhibition of growth and induction of apoptosis, as measured by 3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyl-tetrazolium (MTT) assay, fluorescence microscopy, DNA fragmentation, and flow cytometry analysis. The increase in apoptosis was associated with the proteolytic activation of caspases, Bid cleavage, insertion of pro-apoptotic Bax into the mitochondria, release of cytochrome
【 授权许可】
CC BY
© 2013 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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