Cytotoxic Effects of Fucoidan Nanoparticles against Osteosarcoma

Marine Drugs

Ryuichiro Kimura¹  Takayoshi Rokkaku¹  Shinji Takeda³  Masachika Senba² 

[1] Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan; E-Mail:;Department of Pathology, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan; E-Mail:;Kanehide Bio Co., Ltd., 5-2-2 Nishizaki-cho, Itoman, Okinawa 901-0305, Japan; E-Mail:

关键词: fucoidan;    nanoparticle;    osteosarcoma;    apoptosis;    lung metastasis;   

DOI  :  10.3390/md11114267

来源: mdpi

【 摘 要 】

In this study, we analyzed the size-dependent bioactivities of fucoidan by comparing the cytotoxic effects of native fucoidan and fucoidan lipid nanoparticles on osteosarcoma in vitro and in vivo. In vitro experiments indicated that nanoparticle fucoidan induced apoptosis of an osteosarcoma cell line more efficiently than native fucoidan. The more potent effects of nanoparticle fucoidan, relative to native fucoidan, were confirmed in vivo using a xenograft osteosarcoma model. Caco-2 cell transport studies showed that permeation of nanoparticle fucoidan was higher than native fucoidan. The higher bioactivity and superior bioavailability of nanoparticle fucoidan could potentially be utilized to develop novel therapies for osteosarcoma.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.