Vitamin D and Immune Function

Nutrients

Barbara Prietl¹  Gerlies Treiber¹  Thomas R. Pieber¹ 

[1] Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, A 8036 Graz, Austria;

关键词: vitamin D;    autoimmunity;    immune cells;    adaptive immunity;    innate immunity;    cholecalciferol;    calcitriol;    25(OH)D;   

DOI  :  10.3390/nu5072502

来源: mdpi

【 摘 要 】

Vitamin D metabolizing enzymes and vitamin D receptors are present in many cell types including various immune cells such as antigen-presenting-cells, T cells, B cells and monocytes. In vitro data show that, in addition to modulating innate immune cells, vitamin D also promotes a more tolerogenic immunological status. In vivo data from animals and from human vitamin D supplementation studies have shown beneficial effects of vitamin D on immune function, in particular in the context of autoimmunity. In this review, currently available data are summarized to give an overview of the effects of vitamin D on the immune system in general and on the regulation of inflammatory responses, as well as regulatory mechanisms connected to autoimmune diseases particularly in type 1 diabetes mellitus.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.