Chemopreventive Potential of Flavonoids in Oral Squamous Cell Carcinoma in Human Studies

Nutrients

Marcello Iriti¹ 

[1] Department of Agricultural and Environmental Sciences, Milan State University, via G. Celoria 2, Milan 20133, Italy

关键词: oral cancer;    polyphenols;    anthocyanins;    tea;    black raspberry;    nanochemoprevention;    nanoparticles;    transmucosal oral delivery;   

DOI  :  10.3390/nu5072564

来源: mdpi

【 摘 要 】

Evidence available from nutritional epidemiology has indicated an inverse association between regular consumption of fruits and vegetables and the risk of developing certain types of cancer. In turn, preclinical studies have attributed the health-promoting effects of plant foods to some groups of phytochemicals, by virtue of their many biological activities. In this survey, we briefly examine the chemopreventive potential of flavonoids and flavonoid-rich foods in human oral carcinogenesis. Despite the paucity of data from clinical trials and epidemiological studies, in comparison to in vitro/in vivo investigations, a high level of evidence has been reported for epigallocatechin gallate (EGCG) and anthocyanins. These flavonoids, abundant in green tea and black raspberries, respectively, represent promising chemopreventive agents in human oral cancer.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.