期刊论文详细信息
Molecules | |
Synthesis of Tricyclic Condensed Rings Incorporating the Pyrazole or Isoxazole Moieties Bonded to a 4-Piperidinyl Substituent | |
Giansalvo Pinna1  Giovanni Loriga2  Gérard A. Pinna1  | |
[1] Dipartimento di Chimica e Farmacia, Università di Sassari, Via F. Muroni 23/A, 07100 Sassari, Italy; E-Mail:;C.N.R. Istituto di Farmacologia Traslazionale, UOS Cagliari, Edificio 5, Loc Piscinamanna, 09010 Pula (CA), Italy; E-Mail: | |
关键词: heterocyclization; hydrazine; hydroxylamine; tricyclic isoxazoles; tricyclic pyrazoles; | |
DOI : 10.3390/molecules18078147 | |
来源: mdpi | |
【 摘 要 】
In this paper we report the synthesis of new compounds based on the pyrazole and isoxazole framework fused to a cycloalkene unit, and bearing as a substituent the 1-piperidinyl group as new examples of potential antipsychotic molecules. The general synthesis involves the acylation of a chloro-substituted cyclic ketone with a 1-substituted piperidine-4-carboxylate derivative, followed by heterocyclization of the formed 1,3-dioxo compound with a hydrazine or hydroxylamine.
【 授权许可】
CC BY
© 2013 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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