Synthesis of Tricyclic Condensed Rings Incorporating the Pyrazole or Isoxazole Moieties Bonded to a 4-Piperidinyl Substituent

Molecules

Giansalvo Pinna¹  Giovanni Loriga²  Gérard A. Pinna¹ 

[1] Dipartimento di Chimica e Farmacia, Università di Sassari, Via F. Muroni 23/A, 07100 Sassari, Italy; E-Mail:;C.N.R. Istituto di Farmacologia Traslazionale, UOS Cagliari, Edificio 5, Loc Piscinamanna, 09010 Pula (CA), Italy; E-Mail:

关键词: heterocyclization;    hydrazine;    hydroxylamine;    tricyclic isoxazoles;    tricyclic pyrazoles;   

DOI  :  10.3390/molecules18078147

来源: mdpi

【 摘 要 】

In this paper we report the synthesis of new compounds based on the pyrazole and isoxazole framework fused to a cycloalkene unit, and bearing as a substituent the 1-piperidinyl group as new examples of potential antipsychotic molecules. The general synthesis involves the acylation of a chloro-substituted cyclic ketone with a 1-substituted piperidine-4-carboxylate derivative, followed by heterocyclization of the formed 1,3-dioxo compound with a hydrazine or hydroxylamine.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.