Chemical and Colloidal Stability of Carboxylated Core-Shell Magnetite Nanoparticles Designed for Biomedical Applications

International Journal of Molecular Sciences

Márta Szekeres³  Ildikó Y. Tóth³  Erzst Illés³  Angéla Hajdú⁶  István Zupkó⁵  Katalin Farkas⁴  Gปor Oszlánczi¹  László Tiszlavicz² 

[1] Department of Public Health, University of Szeged, Dóm tér 10, H-6720 Szeged, Hungary; E-Mail:;Department of Pathology, University of Szeged, Állomás u. 2, H-6720 Szeged, Hungary; E-Mail:;Department of Physical Chemistry and Materials Science, University of Szeged, Aradi Vt. 1, H-6720 Szeged, Hungary; E-Mails:;Department of Laboratory Medicine, University of Szeged, Semmelweis u. 6, H-6720 Szeged, Hungary; E-Mail:;Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 1, H-6720 Szeged, Hungary; E-Mail:;Laboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University, H-1089 Budapest, Nagyvárad tér 4, Hungary; E-Mail:

关键词: carboxylated magnetite nanoparticles;    core-shell nanoparticles;    adsorption;    surface complexation;    chemical stability;    iron dissolution;    colloidal stability;    particle charge;    biocompatibility;    biomedical application;   

DOI  :  10.3390/ijms140714550

来源: mdpi

【 摘 要 】

Despite the large efforts to prepare super paramagnetic iron oxide nanoparticles (MNPs) for biomedical applications, the number of FDA or EMA approved formulations is few. It is not known commonly that the approved formulations in many instances have already been withdrawn or discontinued by the producers; at present, hardly any approved formulations are produced and marketed. Literature survey reveals that there is a lack for a commonly accepted physicochemical practice in designing and qualifying formulations before they enter in vitro and in vivo biological testing. Such a standard procedure would exclude inadequate formulations from clinical trials thus improving their outcome. Here we present a straightforward route to assess eligibility of carboxylated MNPs for biomedical tests applied for a series of our core-shell products, i.e., citric acid, gallic acid, poly(acrylic acid) and poly(acrylic acid-co-maleic acid) coated MNPs. The discussion is based on physicochemical studies (carboxylate adsorption/desorption, FTIR-ATR, iron dissolution, zeta potential, particle size, coagulation kinetics and magnetization measurements) and involves in vitro and in vivo tests. Our procedure can serve as an example to construct adequate physico-chemical selection strategies for preparation of other types of core-shell nanoparticles as well.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland