Two Anti-inflammatory Steroidal Saponins from Dracaena angustifolia Roxb

Molecules

Hui-Chi Huang⁶  Ming-Kuem Lin⁶  Syh-Yuan Hwang³  Tsong-Long Hwang²  Yao-Haur Kuo⁴  Chi-I Chang¹  Chung-Yi Ou⁵ 

[1] Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 912, Taiwan;Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan;Endemic Species Research Institute, Council of Agriculture, Nantou 552, Taiwan;Division of Herbal Drugs and Natural Products, National Research Institute of Chinese Medicine, Taipei 211, Taiwan;Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung 404, Taiwan;Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan

关键词: Agavaceae;    Dracaena angustifolia Roxb;    steroidal saponins;    drangustosides A–B;    anti-inflammatory activity;   

DOI  :  10.3390/molecules18088752

来源: mdpi

【 摘 要 】

Two new steroidal saponins, named drangustosides A–B (1–2), together with eight known compounds 3–10 were isolated and characterized from the MeOH extract of Dracaena angustifolia Roxb. The structures of compounds were assigned based on 1D and 2D NMR spectroscopic analyses, including HMQC, HMBC, and NOESY. Compounds 1 and 2 showed anti-inflammatory activity by superoxide generation and elastase release by human neutrophils in response to fMLP/CB.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.