Contributions of Microdialysis to New Alternative Therapeutics for Hepatic Encephalopathy

International Journal of Molecular Sciences

Liliana Rivera-Espinosa³  Esaú Floriano-Sánchez⁵  José Pedraza-Chaverrí²  Elvia Coballase-Urrutia¹  Aristides Sampieri⁶  Daniel Ortega-Cuellar⁴  Noemí Cárdenas-Rodríguez¹ 

[1] Laboratory of Neurochemistry, National Institute of Pediatrics, Mexico D.F. 04530, Mexico; E-Mail:;Department of Biology, Faculty of Chemistry, University City, UNAM, Mexico D.F. 04150, Mexico; E-Mail:;Laboratory of Pharmacology, National Institute of Pediatrics, Mexico D.F. 04530, Mexico; E-Mail:;Nutrition Laboratory, National Institute of Pediatrics, Mexico D.F. 04530, Mexico; E-Mail:;Section of Research and Graduate Studies, IPN, Mexico D.F. 11340, Mexico; E-Mail:;Laboratory of Molecular Biology and Genomic, Faculty of Sciences, University City, UNAM, Mexico D.F. 04150, Mexico; E-Mail:

关键词: microdialysis;    hepatic encephalopathy;    alternative therapeutics;   

DOI  :  10.3390/ijms140816184

来源: mdpi

【 摘 要 】

Hepatic encephalopathy (HE) is a common complication of cirrhosis, of largely reversible impairment of brain function occurring in patients with acute or chronic liver failure or when the liver is bypassed by portosystemic shunts. The mechanisms causing this brain dysfunction are still largely unclear. The need to avoid complications caused by late diagnosis has attracted interest to understand the mechanisms underlying neuronal damage in order to find markers that will allow timely diagnosis and to propose new therapeutic alternatives to improve the care of patients. One of the experimental approaches to study HE is microdialysis; this technique allows evaluation of different chemical substances in several organs through the recollection of samples in specific places by semi-permeable membranes. In this review we will discuss the contributions of microdialysis in the understanding of the physiological alterations in human hepatic encephalopathy and experimental models and the studies to find novel alternative therapies for this disease.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland