Separacenes A–D, Novel Polyene Polyols from the Marine Actinomycete, Streptomyces sp.

Marine Drugs

Munhyung Bae²  Heegyu Kim³  Yoonho Shin²  Byung Yong Kim¹  Sang Kook Lee²  Ki-Bong Oh³  Jongheon Shin² 

[1] Division of Agricultural Microbiology, National Academy of Agricultural Science, Rural Development Administration, Suwon 441-707, Korea; E-Mail:;Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 151-742, Korea; E-Mails:;Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, Seoul 151-921, Korea; E-Mails:

关键词: marine actinomycete;    polyene polyol;    cytotoxicity;    isocitrate lyase;   

DOI  :  10.3390/md11082882

来源: mdpi

【 摘 要 】

Separacenes A–D (1–4), novel polyene polyols, were isolated from Streptomyces sp. collected from the southern area of Jeju Island, Korea. The chemical structures of 1–4 were established by NMR, mass, UV, and IR spectroscopy as well as the modified Mosher’s method. Separacenes A–B (1–2), which share an identical planar structure but possess different relative configurations, bear tetraene units flanked by two diol moieties, whereas the stereoisomeric separacenes C–D (3–4) possess a triene moiety between two diol substructures. Separacenes A–D each contain a terminal olefinic methylene. Separacene A displayed inhibitory activity against Candida albicans isocitrate lyase and weak cytotoxicity against both the colon carcinoma cell line HCT-116 and the lung cancer cell line A549.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.