New Benzoxazine Secondary Metabolites from an Arctic Actinomycete

Marine Drugs

Kyuho Moon²  Chan-Hong Ahn³  Yoonho Shin²  Tae Hyung Won²  Keebeom Ko²  Sang Kook Lee²  Ki-Bong Oh³  Jongheon Shin²  Seung-Il Nam¹ 

[1] Arctic Research Centre, Korea Polar Research Institute, Incheon 406-840, Korea; E-Mail:;Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 151-742, Korea; E-Mails:;Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, Seoul 151-921, Korea; E-Mails:

关键词: Arctic;    marine actinomycete;    secondary metabolite;    benzoxazine;    C-1027;    fijiolides;    disaccharide;    isocitrate lyase;   

DOI  :  10.3390/md12052526

来源: mdpi

【 摘 要 】

Two new secondary metabolites, arcticoside (1) and C-1027 chromophore-V (2), were isolated along with C-1027 chromophore-III and fijiolides A and B (3–5) from a culture of an Arctic marine actinomycete Streptomyces strain. The chemical structures of 1 and 2 were elucidated through NMR, mass, UV, and IR spectroscopy. The hexose moieties in 1 were determined to be d-glucose from a combination of acid hydrolysis, derivatization, and gas chromatographic analyses. Arcticoside (1) and C-1027 chromophore-V (2), which have a benzoxazine ring, inhibited Candida albicans isocitrate lyase. Chromophore-V (2) exhibited significant cytotoxicity against breast carcinoma MDA-MB231 cells and colorectal carcinoma cells (line HCT-116), with IC₅₀ values of 0.9 and 2.7 μM, respectively.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.