Delta Opioid Receptor and Its Peptide: A Receptor-Ligand Neuroprotection

International Journal of Molecular Sciences

Meaghan Staples¹  Sandra Acosta¹  Naoki Tajiri¹  Mibel Pabon¹  Yuji Kaneko¹ 

[1] Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612, USA;

关键词: stroke;    delta opioid receptors;    neuroprotection;    DADLE;    neuronal death;   

DOI  :  10.3390/ijms140917410

来源: mdpi

【 摘 要 】

In pursuit of neurological therapies, the opioid system, specifically delta opioid receptors and delta opioid peptides, demonstrates promising therapeutic potential for stroke, Parkinson’s disease, and other degenerative neurological conditions. Recent studies offer strong evidence in support of the therapeutic use of delta opioid receptors, and provide insights into the underlying mechanisms of action. Delta opioid receptors have been shown to confer protective effects by mediating ionic homeostasis and activating endogenous neuroprotective pathways. Additionally, delta opioid agonists such as (D-Ala 2, D-Leu 5) enkephalin (DADLE) have been shown to decrease apoptosis and promote neuronal survival. In its entirety, the delta opioid system represents a promising target for neural therapies.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland